Muscatine County is a county located in the U.S. state of Iowa. As of the 2010 census, the population was 42,745. The county seat is Muscatine. The southeastern border is formed by the Mississippi River. Muscatine County comprises the Muscatine, IA Micropolitan Statistical Area, which is included in the Davenport-Moline, IA-IL Combined Statistical Area.

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